Journal of Clinical Review & Case Reports(JCRC)

Sussex Kidney Unit, University Hospitals Sussex NHS Foundation Trust, Brighton, UK

Publications

• Case Report   
  Baclofen as a Cause of Impaired Consciousness in a Haemodialysis Patient: A Case Report and Literature Review
  Author(s): Dr James Larkworthy, Dr Charlotte Quick and Dr Farid Ghalli*
  
  Baclofen is an agonist of the gamma-aminobutyric acid (GABA) receptor found on both the pre-and postsynaptic neurones in the central and peripheral nervous systems [1]. Binding to GABAB receptors reduces the activation of the neuronal action potentials supplying muscle spindles, resulting in muscle relaxation [2]. This effect is used therapeutically to treat muscle spasticity in conditions such as multiple sclerosis [3]. In addition, the side effects of baclofen, including dizziness and drowsiness, are thought to result from the activation of GABA receptors located in the central and sympathetic nervous systems [2]... Read More»
  

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