Trop2: A Key Player in Oncology - From Research to Clinical Application

Abstract

Marwene Toumi, Istvan Mathe, Adam Toth, Nora Sztrada, Rozsa Farkas, Laura Jurecska and Bardo

This abstract presents an overview of Trop2, a cell surface glycoprotein, and its significance in cancer research. Trop2, also known as tumor-associated calcium signal transducer 2, exhibits minimal expression in healthy tissues but is highly expressed in various malignancies, such as breast, colon, and pancreatic cancer. The level of Trop2 expression directly correlates with the prognosis of these tumors. This glycoprotein plays a pivotal role in tumor cells’ self-renewal, proliferation, invasion, and transformation, making it a crucial molecular marker for detecting tumor malignancy and a potential target for tumor therapy. The review comprehensively explores Trop2’s structure and physiological functions, shedding light on its association with different types of tumors. Additionally, it delves into the advancements in drug development targeting Trop2, with several promising drugs already undergoing clinical trials. By examining Trop2’s role in cancer biology and its potential as a therapeutic point of intervention, this review contributes to the current understanding of Trop2 as a biomarker and a target for innovative cancer treatments.

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