Transdermal and Moisturizing Effects of Novel Supramolecular Hyaluronic Acid

Abstract

Haimiao Wang, Zhongxia Jin, Xia Lu, Lei Wang, Xiyin Sheng, Shaocheng Wang, Tongxun Xu, Peng He and Chen Li

Hyaluronic acid (HA) is an important macromolecular polymer widely existing in skin, which can lock water mole- cules in the skin.Due to the barrier effect of skin stratum corneum, high molecular weight HA cannot enter the deep skin, while low molecular weight HA has ability limited to maintian water.Nowadays, HA injection is widely used as a supplement method, which brings many disadvantages due to its invasiveness.Therefore, in this study, the ionic liquid induction technology was used to transform the macromolecular HA into the supermolecular state. Through in vitro transdermal experiment and human skin moisturizing experiment, it was proved that the supermolecular state HA has better transdermal and skin moisturizing ability, which provide a new potential method for non-invasive exogenous supplementation of HA.

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