Timolol For the Treatment of Infected Pyogenic Granuloma (PG) Over the Nose

Abstract

Heba Yousef al-Ojailand

Abstract: Pyogenic granuloma (PG) is a benign vascular neoplasm, which exhibits several clinical features suggestive of reactive neovascularization. It is common in children and young adults, with a slight predominance in women. PG may occur spontaneously or may result from local trauma. Histologically the lesion of pyogenic granuloma. Proliferating capillaries are often grouped into lobules by dense fibrous bands, hence the synonym lobular capillary hemangioma The lesion is often clutched by an epithelial. On dermoscopy Red homogenous areas intersected by whitish lines – most common in pyogenic granuloma. There are no standard guidelines for the management of PG So invasive or noninvasive approach. Keymessage: Topical timolol therapy may be the first line of treatment for infected pyogenic granulomas; no adverse systemic effects were reported, over delicate areas like the nose - face on young children, older people, where invasive methods are not preferred, topical timolol may be a therapy option. Objectives: to determine whether topical timolol is safe and effective for treating Infected pyogenic granulomas. Methods: We report an A 15-year-old female patient came in with a history of a single, rapidly expanding red lesion on the left side of her nose that had been developing in size for more than a month and was accompanied by minor pain and itching. In addition to unilateral purulent discharge from inside the nose, there was a history of a mild bleeding episode a few days before to consultation. The patient disclosed that she had her nose pierced a month earlier. Suggesting that infected pyogenic granuloma (PG) may coexist. The patient was prescribed timolol twice daily and trimethoprim/polymyxin four times daily with a pyogenic granuloma as the presumptive diagnosis. Results: Significant improvement was noted with topical timolol with reduction of the lesion size decrease of bleeding tendency and here symptoms had resolved. Limitations we observed Effects of treatment only in 8 weeks. Conclusion: Infected pyogenic granulomas may benefit from topical timolol therapy Longer studies are needed to evaluate resolution and recurrence Rates.

PDF