The Subcutaneous Tissue Reaction on Poly (L-lactide-co-caprolactone) based Threads

Abstract

Sulamanidze GM, Sulamanidze MA, Sulamanidze KM, Kajaia AA, Giorgadze SG

The thread-lifting procedure is gaining popularity all over the globe. It is a mini-invasive, rejuvenate procedure with a short downtime. Aesthetic practitioners use various medical devises and thread materials during thread lifting procedures, but thread degradation and tissue reaction on thread implants are currently poorly understood.

Objective: This article will describe tissue reaction and thread changes from implantation to full degradation. Methods: Tissue reaction on L-lactide-co-caprolactone threads was observed on 0, 4, 13, 26, 34, 52, 64, and 72 weeks after implantation in 21 rabbit models. In all groups, except the 26-week group, eight implants were placed in each model. Specifically, four Test Articles-Aptos Excellence Visage poly (L-lactide-co-caprolactone) threads were implanted on the right side in the cranial-caudal direction, and four control articles were implanted on the left side in the cranial-caudal direction.

Results: Analysis of the local tissue reaction showed that the Test Article and the control article caused the same tissue reaction. However, compared with the control article, Test Article was associated with higher numbers of inflammatory cells on 13 and 34–72 weeks. At 72 weeks, the average area of Test Article had decreased by 41.1%. Conclusion: After subcutaneous placement of the APTOS thread, the thread was progressively surrounded by fibrous tissue and exhibited slow degradation (41.1% over 72 weeks). The prolonged tissue reaction guarantees stable and durable tread-lifting procedure results. The ability of Photic tissue repositions, nucleogenesis and neovascularization has a strong influence on skin texture, structure, color and body couture which is provided by APTOS threads composition and structure.

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