The Role Bio-Psychological Factors in Genes ESR1, COMT & SERT on Premenstrual Dysphoric Disorder

Abstract

Seyyed Mohammad Reza Miremadi and Shahin Asadi

Premenstrual dysphoria is a mood disorder that occurs before the menstrual cycle. While the symptoms of PMDD are similar to premenstrual syndrome (PMS), it is much more severe and can lead to extreme mood swings that can interfere with daily life and functioning. Research shows that women with PMS may have changes in genes that affect how the body processes stress and sex hormones. Research into the causes and treatment of PMDD is emerging, but evidence has shown that the condition is strongly influenced by genetic sensitivity to sex hormones. While PMDD is believed to have biological causes, research has shown that environmental variables such as perceived stress can also increase the risk and severity of the condition.

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