The Germinal Triumvirate- Wilms Tumour

Abstract

Anubha Bajaj

Wilm’s tumour is a malignant, paediatric neoplasm originating from nephrogenic blastema which simulates developing renal pa- renchyma.

Additionally, designated as nephroblastoma, tri-phasic embryonal Wilma’s tumour is constituted of varying quantities of blastemal, epithelial and stromal components. Besides, biphasic and mono- phasic neoplasms are frequently discerned. Epithelial and stromal elements may emerge as poorly differentiated to well differenti- ated components. Morphological assessment of tri-phasic Wilm’s tumour is efficacious and confirmatory. However, appropriate cat- egorization of neoplasms composed of pure blastema, epithelium or stroma can be challenging. Extensive tissue sampling, pertinent immunohistochemistry and molecular techniques are advanta- geously adopted in discerning cogent diagnostic features.

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