Tako tsubo Cardiomyopathy in Oncology Clinical Trials

Abstract

Kosov M, Stoyanova K, Ulmane L, Riefler J, Usachev N and Belotserkovsky M

Tako-tsubo cardiomyopathy is a rare reversible clinical disorder that is characterized by transient left-ventricular dysfunction. Diagnosis is based on Mayo Clinic diagnostic criteria and is confirmed with coronary angiography. Various risk factors have been described with the leading role of emotional or physical stress. Tako-tsubo cardiomyopathy in cancer Patient is frequently attributed to either the main disease or chemotherapy. We described 3 cases of Tako-tsubo cardiomyopathy observed in clinical trials-in patients with non-small cell lung cancer, diffuse large B-cell lymphoma, and cholangiocarcinoma. We conclude that a diagnosis of an advanced cancer could be an additional independent risk factor and a possible trigger for developing of Tako-tsubo cardiomyopathy. Considering this, in patients with cancer who are referred to emergency room with complaints of chest pain/discomfort and/or dyspnea, and who are suspected of having acute coronary syndrome, differential diagnosis should include Takotsubo cardiomyopathy. Assessment of causality relationship should be accurately performed in clinical trials as some data from the literature suggest possible causal relationship to certain chemotherapeutic agents.

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