Systematic Review and Meta-Analysis of Traditional Chinese Medicine Bath in the Treatment of Neonatal Jaundice

Abstract

Wei Sun, Xuanyin Zhao, Zexiang Wu, Haiyang Yu, Yan Wang, Yang Zhang, Dan Li, Limei Geng and Yang Yang

Using meta-analysis method, evaluate the clinical efficacy and safety of traditional Chinese medicine bath in the treatment of neonatal hyperbilirubinemia, and use data mining techniques related to the "Ancient and Modern Medical Case Cloud Platform (V2.3.4)" to study the medication rules of the involved traditional Chinese medicine formulas, providing evidence-based medicine for the clinical application of traditional Chinese medicine bath in the treatment of neonatal hyperbilirubinemia. Search the Chinese Biomedical Literature Database (SinoMed), Chinese Academic Journal Online Publishing Database (CNKI), Wanfang full-text database, Chongqing VIP Chinese Science and Technology Journal Database, Cochrane Library, Embase, PubMed, and manually search for randomized controlled clinical trials related to traditional Chinese medicine bath treatment for neonatal hyperbilirubinemia in conference papers, with a time limit from the date of establishment to October 2024.

Two trained researchers independently screened literature and collected research data based on inclusion and exclusion criteria. They used the bias risk assessment tool provided by the Cochrane Collaboration and RevMan 5.3 software to evaluate the quality of the included literature and conduct meta-analysis. The traditional Chinese medicine formulas involved in the included literature were entered into the "Ancient and Modern Medical Case Cloud Platform (V2.3.4)" to explore the medication rules of traditional Chinese medicine bath treatment for neonatal hyperbilirubinemia.

Meta-Analysis: A total of 34 randomized controlled trials (RCTs) were obtained on the treatment of neonatal hyperbilirubinemia with traditional Chinese medicine baths, involving 7965 patients. Among them, 4021 patients were in the experimental group and 3944 patients were in the control group. The total effective rate of traditional Chinese medicine bath combined with conventional treatment in the treatment of neonatal hyperbilirubinemia is better than that of conventional treatment alone; Compared with conventional treatment alone, the combination of traditional Chinese medicine bath and conventional treatment can reduce the total bilirubin level and shorten the treatment time in the treatment of neonatal hyperbilirubinemia. In the treatment of neonatal hyperbilirubinemia, the traditional Chinese medicine formulas often contain drugs with bitter and cold flavors. The method is to clear heat and dampness, promote bile flow and eliminate jaundice. While clearing liver and gallbladder dampness and heat, the spleen and stomach are also taken into account.

The use of bitter and cold drugs is effective in regulating the pathogenic factors of dampness and heat. The medication reflects the use of the method of inhibiting wood and supporting soil to regulate the liver and spleen, and according to the changes in the disease, combined with the symptoms of the child, it is treated accordingly.

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