Synthesis of Some Heterocyclic Compounds Derived from Furfural
Abstract
MS Al-Ajely, I M Shaban
We know that most heterocyclic compounds are drugs or co- drugs. In our investigation furfural was used as a precursor for heterocyclic synthesis, either by ring opening of furfural going to pyrimidine derivative E3 then functionalizing this pyrimidine into its derivatives E8, E10 and cyclization into oxadiazole and thiadiazoles E8, 11. Or the reaction of pyrimidine with dimedon derivatives to afford dimedino pyrimidine derivatives. The second pathway involve the synthesis of oxamyl derivative of pyrmidine E21-25 these compounds were cyclized into new oxadiazoles E24-26. The third pathway involve the synthesis of mucobromic esters E27-29 from MBA acid then these esters were converted into the correspondig lactones E30-32 and E32-36 while reacting MBA with amines affording N-alkyland N-amidolactams. The last pathway was the reaction MBA with methanol, sodium azide to give azidointermeddiate which was cyclized with alkene or alkynes into triazole derivatives E42-49. The synthesized compounds were characterized by IR and some 1 HNMR measurements.