Synergistic Effects of Natural Extracts and Probiotics on Hair Care: A Study on a Novel Complex Formulation

Abstract

Yung-Kai Lin, Yung-Hsiang Lin and Chi-Fu Chiang

With the aging population and increasing life stress, the demand for hair care and anti-hair loss products is rising. Antioxidants play a crucial role in neutralizing free radicals, reducing oxidative stress on hair follicles, and improving scalp health. Current hair loss treatments rely on medications and supplements, but medications often have side effects, and clinical evidence for natural ingredients remains insufficient. This study aims to evaluate the potential effects of the commercially available product, Probiotics Chlorella Pyrenoidesa Powder, on promoting hair growth and preventing hair loss. The results show that the test product has significant antioxidant and hair care effects. In vitro, the product reduced reactive oxygen species (ROS) by 87.7% and modulated gene expression by decreasing androgen receptor (AR) by 38% and increasing vascular endothelial growth factor (VEGF) by 45%, suggesting its potential to prevent hair loss and support hair growth. In human trials, the product reduced hair loss by 37.3% compared to the placebo and increased hair density, with 30.8% of subjects experiencing over a 50% reduction in hair loss. These findings confirm its efficacy in improving hair health.

PDF