Stromal Luteoma of The Ovary as A Cause of Virilization in A Premenopausal Woman

Abstract

Claudia Onetto, Mariana Lopez, Fernando Jerkovich, Susana Vighi, Eugenia Lamas Majek, Silvina Di Lella, Georgina Blanco, Vanesa Straminsky, Gladys Fernandez, Susana Leiderman and Javier Ortiz

An ovarian luteoma is a steroid cell tumor of the ovary that has a very low incidence. It usually occurs in postmenopausal women, presenting with symptoms of hyperestrogenism or else hyperandrogenism because it is a hormone-secreting tumor. We report the case of a 46-year-old female patient referred to the Gynecologic Endocrinology Section for secondary amenorrhea and virilization. Hormone laboratory tests and imaging studies were ordered. Total testosterone levels were suggestive of tumor production. No conclusive evidence of lesions was found, either in the adrenal glands or in the ovaries. Because of the clinical and laboratory suspicion of an androgen-producing tumor of the ovary, bilateral laparoscopic oophorectomy was performed, which revealed a lesion 1.3 cm in size in the left ovary. The lesion was pathologically diagnosed as ovarian stromal luteoma. The patient made good progress after surgery, with remission of hyperandrogenic symptoms.

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