Secondary Adverse Effects of Anti-Vascular Endothelial Growth Factor Therapy in Choroidal Circulation Case Report

Abstract

Arturo Solís Herrera

Recent research has shown that abnormal production of vascular endothelial growth factor (VEGF) is an often finding in ocular pathologies involving neovascularization. The regulating factors that set the production of VEGF are not well understood, and only the presence of hypoxia in tissues is the most studied factor. But the regulation of oxygen levels in tissues is also not well elucidated, so therapies in this regard were not efficient. The availability of technology that allows to manufacture antibodies to the measure, allowed to design antibodies Anti VEGF. However, its therapeutic effects are far from what is expected because more is unknown than is known about VEGF. Therefore, its side effects as well as adverse effects are frequent, and even exceed its positive effects. The antiangiogenic effect of anti-VEGF antibodies is not selective, that is, it does not distinguish between normal vessels and neo-forming vessels. In this paper we report the adverse effects on the blood vessels of retinal and choroidal tissue of the intraocular application of anti-VEGF antibodies, and its impact on the form and function of these tissues.

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