Role of Immunometabolism and Mitochondrial Health in Inflammaging and Fight against Viral Diseases

Abstract

Laiqha Khadri, Mohammad Hosein Ziraksaz and Baber Ghauri

The immune system provides defense against pathogens and functions to maintain tissue homeostasis for the life of the organism. These diverse functions of immunity are bio energetically expensive, requiring precise control of cellular metabolic pathways.

Activation of immune cells by environmental signals results in dramatic reprogramming of their cellular metabolism. The major goal of this metabolic rewiring is to provide the immune cell with sufficient energy (ATP) and metabolic intermediates to perform its effector functions in host defense and tissue homeostasis. In most instances, activated immune cells achieve this goal by simultaneously engaging in *cataplerosis and *anaplerosis.

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