Research Progress on the Relationship between Lipoprotein Associated Phospholipase A2 and Coronary Atherosclerotic Heart Disease
Abstract
Zhang Xianmeng, Gao Fengmin, Zhang Fuya, Fu Beijing, Wen Xin
Coronary atherosclerotic heart disease is a common disease which seriously endangers human health. The incidence rate is increasing year by year and the age of onset is becoming younger. As a kind of Inflammatory factors of vascular, Lipoprotein associated Phospholipase A2 (Lp-PLA2) can promote the progress of inflammation and coronary atherosclerosis, and its serum level can reflect the stability of atherosclerotic plaque. Among the risk factors of coronary heart disease, Lp-PLA2, as a supplement to the traditional risk factors, has a significant reference value for the prediction of coronary heart disease. More and more studies have found that Lp-PLA2 has a significant potential value in evaluating the prognosis of coronary heart disease, especially in acute coronary syndrome patients. This review summarizes the research progress of Lp-PLA2 on the pathogenesis, detection methods, independent risk factors of predicting coronary heart disease and the treatment and prognosis evaluation of coronary heart disease.