Recent update in identifying Cancer Stem Cells
Abstract
Pasupuleti Sreenivasa Rao and Gangapatnam Subramanayam
Last three decades, significant revolutions have been observed in the field of Stem cell biology. Stem cells are quite complex. Several studies revealed their progression and transition of stem cells in various lineages has been effectively characterized in various systems. (CSCs) cancer stem cells remains in a variety of malignancies and they are the primary source of all tumors, which metastasis and relapse of the disease state. Various types of biologically distinct rare populations of “several tumor-initiating” cells have been reported in various cancers. CSCs, are dormant in nature and slow proliferating cells, under certain conditions, which can regenerate into a tumor. The present conventional therapies target only fast multiplying cells within the tumor, which tend to leave the quiescent or slow proliferative cancer stem cell population remains intact, which provides an opportunity to further reinitiate the tumor under favourable conditions. Moreover the current drugs are major failure in eradicating the proliferation of CSCs. Therefore developing new age therapeutics against CSCs is novel strategy, however there are limitations in Identifying CSCs. The Present short review highlights the importance of markers in identifying CSCs different types of cancers.