Probiotic Bifidobacterium Lactis Combined with Lactobacillus Plantarum Effectively Reduced Weight and Intestinal Microbiota

Abstract

Yung Kai Lin, Tao Ping, Yung Hsiang Lin, Wei Chun Hu, Chi Fu Chiang

Probiotics intake can ameliorate body weight and fatty liver development. The fruit and vegetable also performed antiinflammation effects. The fermented vegetable solid drink (FVSD) was combined fruit and vegetable with probiotics and further examining the anti-obesity efficacy in this study. The FVSD promote lipolytic activity effect was examined on OP9 cells and the anti-inflammation effect was performed via Q-PCR analysis on C2BBe1. To investigate the weight management potential and gut microbiota influence. The obese subjects were recruited, and then performed anthropometric measurement and next-generation sequencing (NGS) after FVSD intervention. In the results, the lipolytic activity effects were significantly increased and the LPS induced inflammation response was significantly reversed by FVSD co-treatment. After FVSD administration, obese subjects were significantly ameliorated body weight, body fat weight, and body fat at 4 weeks. And the waist-to-hip ratio was improved at 8 weeks. Both aspartate aminotransferase (AST), alanine aminotransferase (ALT) were significantly improved with anti-fatty liver potential. The NGS analysis suggested FVSD intervention could increase Christensenellaceae and Parabacteroides abundance of subjects’ gut microbiota. In conclusion, FVSD performed a great anti-obese effect in vitro and in vivo.

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