Prediction of Cardiovascular Disease Event in Type 2 Diabetes Mellitus by Gene Variants and Abnormalities of Lipid Profile

Abstract

Alice Jaya Pradha Cheekurthy, Rambabu C and Amit Kumar

Cardiovascular diseases continue to be a leading cause of morbidity and mortality among adults worldwide.A total of 180 subjects, aged 15 years and older were selected for the case control study from of Telangana and Andhra Pradesh states in India. For the study90 diabetic cases and 90 controls were selected.The study aim was to validate the association of gene variants in APOC III(rs121918381), AGT(rs699,rs4762)and lipid abnormalities in prediction of cardiovascular disease event in the discrete study population. The results showed increased values of lipid profile characteristics in both the diabetic cases and some of the controls. The gene variants of APOC III gene are present in 43.9% of the population and AGT gene of rs699 is present in 48.7%. The SNP rs4762 in AGT gene is not reported in our study population. It can be safely concluded that increased lipid profile characteristics and presence of the genetic variants are the risk factors for future cardiovascular event.

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