Phytochemical and Pharmacological Study on the Leaves of Bauhinia Purpurea L. for Antilithiatic Activity

Abstract

Dilip Kumar Chanchal, Mayank Kumar, Archana Dongray, Sakshi Tiwari, Saurabh Gupta and Shahbaz Khan

The main purpose of this study was to investigate the impact of ethanolic concentrate of Bauhinia purpurea L. leaves on lithiatic action in rat. Twenty four rats were divided into 6 groups comprising four animals per groups. The blood was collected from the retro-orbital sinus; serum was separated by centrifugation and analyzed for creatinine and uric acid. Both kidneys from each animal were removed and sectioned for histopathological examination. The results were expressed as mean ± standard error mean (SEM) and the statistical significance was assessed using one-way analysis of variance (ANOVA) followed by Dunnett’s comparison test and p<0.05 was considered significant. In the present in-vivo study, renal stone inciting treatment to rodents came about in hyper-oxaluria. Ethanolic concentrate of B. purpurea L. was exposed to antilithiatic action in rodents where ethylene glycol 0.75% (v/v) utilized as the causing lithiasis specialist. Ethanolic concentrate of B. purpurea (at 100 and 200 mg/kg) showed a portion subordinate noteworthy enemy of lithiatic action on treatment. The concentrate portion of 100 mg/kg likewise caused decrease of Ca, oxalates, P and creatinine in blood serum level the outcomes were found factually noteworthy. The impact of ethanol concentrate of this movement was discovered critical than the reference standard. By and large investigation uncovers that the ethanolic concentrate of B. purpurea L. demonstrates the mellow to direct antilithiatic movement with correlation with cystone

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