Neuroprotection in Perimenopause New Insights for Hormone Therapy

Abstract

Manuela Cristina Russu

Endocrine and Neural Senescence overlap by intertwined complex feedback loops. The variable levels of estradiol, progesterone, DHEA(S), and neurotransmitters -GABA, serotonin, dopamine and glutamate dependent on sexual steroids make women’s brain to suffer from the menarche to menopause, perimenopause being a “critical period”, “a neurological transition state” offering to the scientific and medical communities a “window of opportunity” to delay the onset of brain aging, The modern medical communities are moving from focusing on the treatment of already identified dementia to develop strategies for accurate depiction of predementia conditions/risk factors for brain aging, for prevention and slowing a demented status to progress from early stages of endocrine aging process [1].

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