Membranoproliferative Glomerulonephritis Associated with Type Ii Cryoglobulinemia, Revealing A Gastric Malt-Type Lymphoma (Morocco)

Abstract

Masrour Sara, S Lalouly, N Hamouche, M Chettati, W Fadili and I Laouad

Cryoglobulinemic vasculitis (CV) is a rare systemic disease secondary to vascular deposits of cryoglobulin, an immunoglobulin capable of precipitating in the cold and resolubilizing upon warming. It primarily affects the skin, joints, peripheral nervous system, and kidneys. Renal involvement in CV clinically manifests as rapidly progressive glomerulonephritis or a nephritic syndrome and histologically as membranoproliferative glomerulonephritis (MPGN). CV is often associated with underlying conditions such as chronic infections (notably hepatitis C virus), autoimmune diseases, or certain cancers. Extra nodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT) is a rare subtype of non-Hodgkin lymphoma (NHL) often linked to chronic inflammation. The stomach is the most common anatomical site associated with MALT lymphoma. While renal involvement in NHL is well documented, it is less common in MALT lymphoma. Here, we report an extremely rare case of MALT lymphoma with renal involvement, a rare cause of mixed CV associated with MPGN.

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