Matrix Modeling of the Artificial Cell / Protocell Division with ARTCELL DIVISION SIMULATOR-2009/2010: from Computer Simulation to Experimental Multispectral Investigations Based on Multi-Channel DPSSL Microbeam Setup

Abstract

Bolkhovitinov A. S, Gradov O. V, Gradova M. A, Notchenko A. V, Orekhov F. K

A model of the artificial cell / protocell division is proposed, which al-lows achieving similarity to different forms of cell division and emer-gence of the cell colonies by rearrangement of the parameters. The most characteristic features of cell division reproduced in this model are: cytotomy with a constriction (separatrix); cytokinetic processes after cytotomy; asynchronous nature of cell division; surface dispro-portionation during the cell division (as a consequence, the presence of both symmetrical cytotomy and budding); formation of the topological distortions; the possibility of colonial cell association; the presence of fixed cells and groups of cells (reproductive generators) like CFU and their coordinated operation. Cytokinetic processes are recorded in the systems of undifferentiated artificial cells. Such variability in the artificial cell "cultures" is observed in the form of reversible processes depending on the environmental conditions. Such instability of the regimes, probably, could have taken place in the course of evolution at the first stages of development of reproductive systems in protobionts, when mechanisms of genetic or other structural biochemical stabilization did not yet exist, but was developed during the division of the score for the future selection of these pathways.

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