Macular Amyloidosis, A Type of Pigmentation in Atopic Dermatitis that is Pathogenically Related

Abstract

Kamran Balighi, Rona Nikzad, Maryam Daneshpazhooh and Mahshid Sadat Ansari

Background: Macular amyloidosis (MA) is a chronic pruritic skin condition characterized by hyperpigmentation, primarily affecting the back and extensor surfaces of the extremities. The exact etiology remains unknown; however, genetic and environmental factors, such as chronic friction, appear to play a role. An association between atopic dermatitis and cutaneous amyloidosis has been reported.

Methods: This study evaluates the prevalence of atopy in 40 patients diagnosed with MA.

Results: Atopic dermatitis, asthma, and allergic rhinitis were observed in 20%, 8%, and 20% of patients, respectively. A positive family history of atopy was noted in 90% of patients. Pruritus was significantly more severe in patients with atopic dermatitis (p-value = 0.003).

Conclusions: We recommend considering both personal and family histories of atopy when assessing patients with MA.

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