M7G-related miRNA biomarkers for predicting overall survival outcomes for colon carcinoma

Abstract

Lebin Yuan, Fei Cheng, Zhao Wu, Wei Shen

Colon cancer is the fourth deadliest cancer in the world, accounting for about 10% of all cancer cases in both men and women [1, 2]. The incidence of colon cancer has increased significantly in recent years, global mortality rate of colon cancer is about 50%, which is closely related to dietary habits, genetic factors, age, and smoking [3-6]. The current main treatment modalities include surgery, che- motherapy and radiotherapy, and targeted therapy, more effective treatment strategies are imminent. The search for novel diagnostic biomarkers and effective treatment strategies, and the discovery of COAD-related pathogenesis can provide new insights into the prediction, development, and progression of COAD, and improve optimal adjuvant therapy for patients in routine clinical practice.

PDF