Levels Orexigenic and Anorexigenic Hormones in Adolescents with Obesity

Abstract

Elena V Bolshova, Tetiana M Malinovska and Olga A Vishnevska

Background: About 20 thousands of new cases of obesity (Ob) are first registered in children and adolescents in Ukraine annually (morbidity 2.72/1000, prevalence 13.50/1000 of the corresponding population on 01.01.2016). Adolescent Ob shows catastrophic rise (prevalence 8.9/ 1000 in 2001 vs 28.3/1000 in 2015). Completely unclear the role of Ghr in the etiopathogenesis of obesity in adolescents with HD.

Material and Methods: A total of 39 obese children with HD (14 boys, 15, 1 ± 1, 4 y) and 14 healthy control (mean age 14, 6 ± 1, 2 y) were included into the study. Among patients with HD- 16 patients (41, 03 %) had visceral abdominal obesity (VAOb), 23 patients (58, 97 %) had gluteofemoral obesity (GFOb). Serum Ghrelin, Insulin level, HOMA-IR were studied. Such studies are conducted in Ukraine for the first time.

Results: Overweightt was revealed in 15 (38, 5 %) patients with HD, ObI – in 8 (20, 5 %) people, ObII – in 10 (25, 6 %) persons, ObIII – in 6 people (15, 4 %). The signs of insulin resistance (HOMA-IR > 2, 77; IRI > 20 μIU/mL) were noted in 60 % patients. Serum Ghr level was found significantly lower in obese adolescents compared to that of control group and was dependent on the degree of Ob. The level of Ghr was the lowest (582, 58 ± 59, 37 ng/mL) in patients with ObIII. The level of Ghr was significantly lower (p <0.05) in patients with VAOb than with GFOb (656, 63 ± 113, 16 vs 1212, 13 ± 114, 6 ng/ml, respectively). The levels of hyperinsulinemia and insulin resistance were increased with an increase in the degree of obesity.

Conclusion: Hypothalamic dysfunction, associated with obesity in adolescents, is accompanied by a low serum Ghr level. A high degree of obesity is accompanied by a greater decrease in the Ghr level. A significantly lower Ghr level was registered in abdominal Ob comparing to gluteofemoral type of obesity. Further studies the relationship of Ghr level, insulin resistance and hyperinsulinemia in obese adolescents with hypothalamic dysfunction are required.

PDF