Itraconazole-Associated Purpuric Drug Eruption: A Rare Adverse Effect of a Commonly Prescribed Drug

Abstract

Mahesh Mathur, Sumit Paudel, Sandhya Regmi, Supriya Paude, Nabita Bhattara and Sambidha Karki

Purpuric drug eruption (PDE) is a rare drug reaction characterized by purpuric macules, papules, and confluent plaques predominantly on the lower extremities. The drugs reported to induce purpuric drug eruption are epidermal growth factor receptor inhibitors, ketoconazole, acetylsalicylic acid, penicillin, sulfonamides, indomethacin, lenalidomide, linezolid, vancomycin and itraconazole. Drug induced thrombocytopenia, platelet dysfunction and direct toxic effect of the drug on capillary wall leading to increased capillary fragility are the proposed etiology. There is only a single report of itraconazole- induced purpuric drug eruption in the literature till date.We hereby present a case of 57-year-old female with PDE due to itraconazole.

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