Is there an association of bone mineral density and risk of breast cancer in postmenopausal Saudi women?

Abstract

Saleh Othman

Several studies revealed an association between high bone mineral density (BMD) and the increased risk for developing breast cancer (BC).

Aim: Explore if there is an association between BMD and BC risk in postmenopausal Saudi (PMS) women.

Material and Method: In a retrospective cohort study of 1145 PMS women age range from 46 – 85 year (mean = 55 year). The average time period of menopause 4 years.We reviewed BMD of all patients performed between October 2012 and November 2018. All patients had BMD measurements of lumbar spine L2-L4 and right femoral neck in gm/cm².

Results: The T-score was used for analysis of the results. Among the total patient studied 195 (17%) were found to have BC group 1 (G1) while 950 (93%) without BC group 2(G2). Analysis of lumbar spine T-score in G1 showed that: 29 % had osteoporosis, 37% osteopenia and 34% had normal BMD and in G2 40% had osteoporosis, 31% osteopenia and 29 had normal values. Results showed prevalence of osteoporosis in G1 was significantly lower than in G2 (p =0.002) while there was no significant difference between the two groups with osteopenia and normal BMD results (p = 0.06 and 0.205 respectively).

Conclusion: PMS women with BC had higher BMD at time of diagnosis compared to their counterpart without BC.

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