Is Low Molecular Weight Heparin the Treatment of choice for Neonatal Thrombosis?

Abstract

Muhammad Umar Sahi

A borderline preterm baby is born with an emergency caesarean section. The baby is found to have an unprovoked occlusive thrombosis in the left renal vein and inferior vena cava. There are no obvious risk factors for thrombosis. The baby is commenced on un-fractionated heparin (UFH) followed by a prolonged course of low molecular weight heparin (LMWH) based on the guidelines adopted from adult evidence. You wonder if this is reasonable to treat neonates as per adult guidelines given the great differences between adult and neonatal clotting parameters.

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