Improvement of Bacterial Vaginosis and Vulvovaginal Candidiasis with a New Lactobacillus Strains Association: A Pilot Study

Abstract

Franco Vicariotto, Filippo Murina

Bacterial vaginosis and vulvo-vaginal candidacies are bacterial infections widely spread among women in childbearing age. These infections are associated with altered or disturbed vaginal microbiota, in a condition defined as vaginaldysbiosis. Restoration of the lactobacilli flora seems a promising strategy for the treatment of these pathologies.

The efficacy and safety of a new vaginal composition, containing three Lactobacillus strains selected for their activity against urogenital pathogens, was assessed in a pilot clinical trial for the treatment of bacterial vaginosis and vaginal candidacies. The study involved women with diagnosis of bacterial vaginosis (30) or vulvovaginal candidacies (24). Vaginal capsules, containing the three Lactobacillus strains, were administered following one application per die for ten consecutive days. Patients received gynecological examinations before and after treatment, with objective examination, assessment of clinical symptoms severity and vaginal wet mount microscopy.

The treatment showed a complete resolution in 60% of bacterial vaginosis cases and around 40% in vulvo-vaginal candidacies cases. Further analyzing the subgroup characterized by a recurrent vaginal candidacy, the success rate was significantly higher than in the acute cases, showing a stronger effect of the product against persistent and chronic condition. The product showed a resolution of the vaginal dysbiosis through vaginal wet mount examination and no adverse effect were reported.

In conclusion, the presented clinical data support the use of the Lactobacillus vaginal composition for the treatment of bacterial vaginosis and vulvo-vaginal candidacies.

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