Impact of Liver Cirrhosis on the Occurrence of Diabetes Mellitus and Glucose Intolerance among Liver Cirrhosis Patients in European Gaza Hospital: A Retroactive Study

Abstract

Khaled Matar, Oday Bakri, Iyad Abo Jazr, Salah Al Shami, Mahmoud Al SheikhAli, Hassan Rosros, Rami Salut, Mohammed Hejazi, Iyad Khamaysi and Deema naim

Background: Third of liver cirrhosis patients have diabetes mellitus. In addition, most of patients with cirrhosis may be glucose intolerant. This study aimed to shed light on the impact of liver cirrhosis on the occurrence of diabetes mellitus among liver cirrhosis patients.

Materials and Methods: This study is a retrospective analytical study design. The study was a descriptive study. The study was conducted at the gastroenterology outpatient clinic in European Gaza Hospital. Data were collected retrospectively from patients records and from patients themselves when attending at the clinic. The study was conducted during the period from September 2022 to February 2023. The study tool is a self-designed questionnaire based on most recent published literature. The questionnaire included basic information about the patients, data related to liver cirrhosis and some laboratory work done for the patients.

Results: A total of 70 patients were included in the study, with more than half being male (60%). The mean age of participants was 61.97 ± 11.54 years. The most frequent cause of liver cirrhosis among participants was cryptogenic (54.3%), and two-thirds of the participants had comorbid conditions besides liver cirrhosis, with diabetes mellitus being the most frequent (54.3%). The majority of participants were overweight or obese, with a mean body mass index of 31.15 kg/m2. Ultrasound imaging showed that most participants had severe steatosis (88.6%) and a shrunken liver (72.9%). The laboratory findings showed raised mean alanine transaminase (ALT) and aspartate aminotransferase (AST) levels, with high levels of triglycerides and cholesterol.

Conclusion: Most participants were overweight or obese. More than half of the participants had comorbidities, including diabetes mellitus, and cryptogenic liver cirrhosis was the most prevalent etiology. Most liver ultrasounds indicated significant steatosis. Participants had increased alanine transaminase, aspartate aminotransferase, triglycerides, and total bilirubin.

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