Hypoglycemia Following Celecoxib Use in a Non-Diabetic Patient: A Case Report

Abstract

Farshid Mohammadi, Ramin Mansouri, Mehta Razzaghi, Hosna Rezaei and Sara Alipour

Background: Hypoglycemia typically arises due to insulin or insulin-producing drugs used to treat diabetes. It can also occur from exposure to other medications like alcohol. To diagnose hypoglycemia, the first step is to determine whether it is hyperinsulinemia or non-hyperinsulinemia. To differentiate between the two, the drug history of the patient should be examined.

Case presentation: A 23-year-old male was diagnosed with hypoglycemia and hypoglycemia due to Celecoxib consumption. After ruling out potential causes, drug complication was concluded as the most probable cause. The patient was advised to discontinue Celecoxib and follow-ups at 3, 6 and 12 months showed normal blood glucose levels and no hypoglycemic symptoms.

Conclusion: Research results suggest that celecoxib and valdecoxib may be used as glucokinase-activating compounds and lead to hypoglycemia. These drugs reduce blood glucose levels by exerting their effects not only on the liver, but also in the pancreas.

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