Hypertensive and Metabolic Issues in Nephrolithiasis with Pregnancy

Abstract

Hany Mahmoud Abd El Hameed, Shaimaa Belal and Mohamed Elatrebi

Background: Renal stones are correlated clinically with forthcoming development of hypertension, diabetes, and the metabolic syndrome. Objective of the study: To evaluate and investigate whether stone formation before pregnancy is correlated with metabolic and hypertensive medical development emergence in gestation. The research team hypothesis was based on that stone development is considered a potential marker of metabolic disease and will be linked with greater risk for maternal complications in pregnancy.

Methodology: We conducted a two-group cohort study of women who delivered infants at El Sahel teaching Hospital 2015to 20118. Women with abdominal imaging investigate (computed tomography or sonography) before pregnancy were incorporated in the analysis. 923 cases were assessed for eligibility for the study 817 cases were eligible consequently they were categorized into stone formers (126 cases) and non-stone formers (691 cases .finally 110 cases were enrolled for each arm of the study 8 cases were lost during follow up in the stone former research group and 6 cases were lost during follow up in non-stone former research group. Gestational outcomes in women with documented renal stones by imaging were compared with those of women without stones on imaging. Females with preexisting chronic kidney disease, hypertension, and diabetes were excluded.

Results: Stone former research group had statistically significantly more frequent hypertension, gestational hypertension, preeclampsia and preterm (p values=0.005,0.035,0.034,0.017, consecutively) as well as higher Maximum systolic blood pressure, diastolic blood pressure and glucose tolerance test (p values<0.001,0.030,0.039, consecutively).

Conclusions: In women without preexisting diabetes, hypertension, and CKD, a history of nephrolithiasis was associated with gestational diabetes and hypertensive disorders of pregnancy, especially in women with high first trimester body mass index.

PDF