Histo-Morphological Assessment of the State of Microcirculation in Acute Experi-mental Pancreatitis

Abstract

Abbasova HF*

In order to study the features of hemolymphcirculation disorders in the pancreas that occur during acute pancreatitis (AP), morphological studies were carried out on experimental animals–48 rabbits in an intact state (8 rabbits) as well as 12, 24, 48 hours after modeling AP (10 rabbits in each series).

A model of AP was created by injecting into the pancreatic tissue of these animals a special complex, consisting of a mixture of bile with chloroform, at a dosage of 10 mg/100 g of weight under anesthesia after an upper laparotomy. In all series the morphostructure of the pancreas and its vascular microcirculatory (MC) system was studied.

It was detected that during the first day after modeling blockage of the background of a developing blockage of the microhemocirculaty (MHC)-link of microcirculatory MC system, simultaneously activated the drainage and transport functions of the microlymphcirculatory (MLC)-link of the MC system and the lymphatic system generally. On the third day a complete blockage of the MHC-link of the MC system occurs, while the MLC-link, despite the destruction of part of the lymphcapillaries, mostly continues to carry out its drainage and transport function. The blockage of the MHC-link of the MC system with the simultaneous activation of the drainage and transport function of the MLC-link of MC system and the lymphatic system, generally explains the low clinical effectiviness of conventional infusion-transfusional therapy for patients with AP and this is the rationale for the use of direct endolymphatic therapy.

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