Green Synthesis, Characterization, In Silico ADMET Profiling, Molecular Docking Studies of 3, 4-Dihydropyrimidin-2-(1H)-ones Against Voltage-Gated Calcium Channel (4MS2) Receptor

Abstract

Rakesh D Amrutkar

The present work involves design, synthesis and evaluation of derivatives of 3,4-dihydropyrimidine 2 one. Using pyrim- dine as a core structure for design of novel pyrimidine derivatives which are calcium channel blocker, Derivatives of 3,4-di- hydropyrinidine-2-one was synthesized by microwave assisted synthesis method. There are ten derivatives are synthesized by microwave assisted synthesis in laboratory. The entire synthesized compound was tested using Insilco parameters like Pass online data, SwissADME parameters and toxicity parameters by using protox II. All the synthesized compound tested by pass online software for its biological activity. All the synthesized compounds reflelects various activities like antihyper- tensive, antianginal, antiviral, antifungal and all of them are calcium channel blockers.

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