Functional Connectivity and Regional Homogeneity Alterations in Migraine Patients: A Protocol of Systematic Review and Meta-Analysis

Abstract

Yu-Ling Cui, Qiang Xu, Yu-Ting Li, Yang-Ming Zhang, Mr. Jing-Ting Sun, Ze-Yang Li, Min-Hua Ni, Lin-Feng Yan, Guang-Bin Cui, Wen Wang, Zhu-Hong Chen

Objective: There are numerous functional magnetic resonance imaging (fMRI) studies examining the cerebral function of migraine patients using regional homogeneity (ReHo) and functional connectivity (FC) measurements. However, these studies generally report inconsistent conclusions. We will perform a systematic review and meta-analysis of this body of literature, aiming to identify consistent conclusions regarding cerebral functional changes in migraine patients and to describe potential future directions.

Methods: Two investigators will independently screen studies published in online databases (i.e., Medline, Cochrane Library, PubMed, and Web of Science) from the database inception to June 1, 2021. By discussing with a third investigator, any disagreement will be resolved and will attain consensus. A coordinate-based meta-analysis will then be performed with an activation likelihood estimate (ALE) random-effects model.

Results: The cerebral FC and ReHo altered regions in migraine patients will be elucidated in this meta-analysis.

Conclusion: This study will reveal cerebral functional changes of migraine patients based on current literature to identify consistent conclusions and to describe potential future direction.

PDF