Flow Resistance in Glaucoma, POAG is Poorly Understood

Abstract

Karan Aggarwala

It has come to be widely recognized that the “conventional” drainage pathway of aqueous humor is slowed by resistance of fluid outflow caused in part by anatomical/mechanical properties of the trabecular meshwork (TM). But what is less widely recognized is that the major part of TM has cellular mechanisms for REDUCING resistance. The first layer of TM demonstrates large inter-cellular spaces between loosely woven connective tissue and endothelial cells, while the second layer of TM has “sheets” or “layers of tissue” composed of collagen, elastin, and protein-glucose complexes [1-3].

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