Factors of Postural Asymmetry (FPA) At The Pre and Subclinical Stages of the Development of 3D Deformity of the Vertebral Complex

Abstract

Tatyana Khaimina, Tatyana Avaliani, Marina Karpenko, Michail Dudin and Dmitry Pinchuk

In the pathogenesis of typical scoliosis, as a three-dimensional deformation, the process of formation of its horizontal component is of particular interest. From the point of view of the functional anatomy of the vertebral complex, appearance of this component is directly related to the work of the transverso-spinal muscles. Thus, their contraction on the left side results in a rotational displacement of the vertebral bodies to the right, and the same phenomenon on the right causes a left-sided rotation of the main bone elements of the supporting column of the spine. It has already been shown that longterm asymmetric contraction of these muscles is a key at the subclinical stage of the transition of a healthy spine to the “scoliotic” status [1-3]. The method of blood serum bioassay (BT SC) has confirmed our assumption that among the participants in the pathogenesis of progressive scoliosis there are so-called neuropeptide factors of postural asymmetry (FPA), which have an ability to lateralize the activity of motor neurons in the spinal cord. These were natural regulators - oxytocin and arginine-8-vasopressin, and this ability appears in a case of a multiple increase in their concentration. Determination of their quantitative characteristics using ELISA showed high correlations between the levels of these factors and the process of spinal column deformation at the pre-and subclinical stages of scoliosis development.

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