Exposome, Interactome and Systemic Lupus Erythematosus (SLE)-an Evolving Theory and Ongoing Needs

Abstract

Ritasman Baisya

The development and progression of SLE involve complex interactions between genetic, environmental, and immunological factors. Much research is needed to fully elucidate the mechanisms by which these exposures contribute to the development and severity of SLE. Exposome studies, which aim to comprehensively assess an individual's environmental exposures throughout their lifetime, can provide valuable insights into potential risk factors for SLE. By examining the exposome in conjunction with genetic and epigenetic factors, researchers can identify associations between specific exposures and the development or severity of the disease. This approach can help uncover modifiable risk factors and guide the development of preventive strategies for SLE, regardless of an individual's genetic background. Furthermore, an "interactome" approach, which investigates the complex network of interactions between genes, proteins, and environmental factors, can be instrumental in understanding SLE at a systems level. By integrating data from the exposome, genome, and epigenome, researchers can gain a more comprehensive understanding of the disease's etiology, identify populations at risk, and potentially develop personalized prognostication and therapeutic approaches.

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