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Exosome, is it a Benefit or Harm for Cancer?
Abstract
Dina Sabry and Abeer Mostafa
Exosomes are nanoparticles formed of plasma membrane that surround the genetic information in the form of miRNA. Exosomes provide a mean of cellular communication. Exosomes can affect the neighboring cells or transmitted to distant organs through body fluids. The function of exosomes depend on their origin. Cancer cell derived exosomes contain certain types of miRNA that enhance tumor initiation and metastasis. On the other side exosomes derived from another types of cell like dendritic cells or MSCs can be used for cancer treatment. Loading these types of exosomes with certain miRNA can inhibit tumor growth and increases the chemo sensitivity.