Evaluation of Single Agent Cisplatin versus Cisplatin and 5 Flouro Uracil Chemotherapy in Cervical Cancer Patients in India

Abstract

Biswas Som

Cervical cancer is the most common gynecological cancer in Indian women. We conducted this study to assess whether single-agent Cisplatin was better than Cisplatin and 5 flourouracil chemotherapy in cervical cancer patients in India.The aim was to assess tumor response of weekly injections of single-agent Cisplatin versus Cisplatin and 5 flouro uracil chemotherapy in women with carcinoma cervix with FIGO stages IB2 to IIIB. 54 patients were included in this study who completed the treatment. Disease was assessed prior to treatment by pelvic examination and contrast enhanced MRI of the abdomen and pelvis. Response was assessed 1 month after completion of treatment by physical examination and 3 months after also by MRI. There was a complete response rate of 88% after 3 months in patients getting Cisplatin and 5 flouro uracil chemotherapy compared to response rate of 80% in those getting only Cisplatin. The mean duration of treatment was 60 days. In conclusion, combination chemotherapy with cisplatin and 5 FU along with radiotherapy in patients with locally advanced squamous cell carcinoma of cervix was well tolerated and slightly better than single agent chemotherapy with Cisplatin alone.

PDF