Evaluation of Sinapic Acid to Ameliorate Ionizing Radiation Induced Peripheral Blood Mononuclear Cell Death
Abstract
Prasenjit Mondal, Adity Bose, Sarmishtha Chanda
Introduction: The UV radiation is known as a potential environmental carcinogen which causes damages of macromolecules like DNA, RNA, lipid, and protein inside the cell and eventually causes cell death. Persons who chronically exposed to UV radiation due to occupational or environmental exposure have a potential risk to develop cancer of the skin and internal organs. Polyphenols have a promising role in scavenging reactive oxygen species developed in our body due to a variety of exposure including radiation. In the present study, we are therefore evaluating the role of sinapic acid (SA), a polyphenol, in scavenging UV radiation-induced generation of reactive oxygen species and eventual cell death. We have studied the biological activity of SA as a potential antioxidant on human peripheral blood mononuclear cells taken from human volunteers.
Methods : Graded concentration of SA in different solvent mediums was applied to UV exposed peripheral blood mononuclear cells for evaluating the best effective delivery system and concentration against UV radiation.
Result: After series of experiments, we have observed that even at 10 µM concentration, SA is effective against UV induced cellular death.
Conclusion: Finally, from this work we are inviting lots of works in this field to establish this molecule as a medicine to reduce radiation-induced cellular death