Evaluation of Environmental Influence of Arsenic Compounds on Patients Suffering From Type 2 Diabetes

Abstract

Hafiza Amina Matti, Saima Shokat, Riffat Iqbal, Muhammad Zubair and Samreen Riaz

Background: Diabetes Mellitus type 2 is a metabolic ailment. It is a condition when insulin is produced by our body but, it is not used properly by us. The number of diabetic patients is increasing in the whole world. The problem of obesity is also very closely related to it, which itself is expanding. The individuals diagnosed with type 2 Diabetes Mellitus have high chance of microvascular problems (like nephropathy). They are also at the verge of facing macrovascular ailments (like cardiovascular comorbidities). These issues are usually because of hyperglycemia and specific mechanisms of the insulin resistance (metabolic) disorder. Environmental factors and genetic features result in different pathophysiological issues. Arsenic is the chemical that act as diabetogenic agent as it effect the functioning of pancreatic beta cells and also cause insulin resistance through several ways like oxidative stress by the production of free radicals in the body and also due to the disturbance of protein hormone that disrupt insulin sensitivity. Methods: Initially data through Questionnaire and samples of 100 diabetic patients and 100 normal healthy persons were collected. Then different parameters including AST, ALP, AST, Creatinine, Bilirubin, Urea, and HBA1c were estimated. Then the main parameter (Arsenic) was evaluated. Then Statistical analysis was done on collected data of both groups.
Results: All the parameters including glucose level was higher in diabetic patients. By comparing values of two groups statistically, it was observed that arsenic levels in diabetic group are far higher than the control group and the value of diabetic group is exceeding than the standard value.
Conclusion: So, arsenic level was higher in diabetic persons and working as diabetic agent. There should be no residence near rice paddies or any arsenic rich area. We should promote the usage of PPE “personal protective equipment” in order to avoid arsenic exposure.

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