Epigenetic Reprogramming: Evolutionary Synergies for the Prevention of Emerging Diseases
Abstract
Claudio Lombardo
From the perspective of systems theory, human health results from a dynamic balance between environmental, biological, and behavioral factors [1]. The interaction between endocrine-disrupting chemicals (EDCs), sedentary lifestyles, ultra- processed food consumption, and disconnection from natural stimuli disrupts circadian rhythms, metabolism, and brain functions, generating a state of neuroendocrine dysregulation and systemic inflammation [1,2]. Exposure to EDCs compromises hormonal and neurochemical regulation, with transgenerational effects that increase the risk of psychiatric and metabolic disorders in future generations, exacerbated by the role of adipose tissue as a bioaccumulator of toxins [3,4]. Emerging diseases, once exclusively associated with viral infections (such as COVID-19 and the Zika virus), now also include metabolic, neurodegenerative, and psychiatric disorders that are rapidly increasing due to circadian disruption, chronic inflammation, and loss of environmental variability [3,5,6]. These factors operate systemically, leading to neurochemical imbalances, hormonal dysfunctions, and impaired adaptive responses [7]. To counteract these effects, a systemic approach is necessary, based on circadian rhythm regulation, exposure to nature and cold, neurofeedback, functional nutrition, and hormonal balance [8]. In this context, epigenetic reprogramming emerges as a key mechanism to modulate gene expression without altering DNA, enabling the reversal of environmental damage through targeted interventions in lifestyle, diet, and neuroprotection [9].
These strategies represent a new frontier in the prevention and treatment of neuroendocrine dysfunctions and emerging diseases, laying the foundation for an integrated therapeutic paradigm adapted to the needs of modern society.