Effects of Curcuma Longa and Galega Orientalis Herbal Remedies on Homeostatic Renal Functions in Rats with Diabetes Mellitus and Acute Renal Failure

Abstract

Aizman Roman I, Kozlova Anna P, Gordeeva Elizaveta I, Lomovsky Igor O

Aim: To study the effects of phytopreparations Curcuma longa and Galega orientalis on homeostatic renal functions in rats with diabetes mellitus (DM) and acute renal failure (ARF) models.

Materials and methods: The experiments were performed in 2 series on male Wistar rats (n = 60) with a model of diabetes mellitus (the 1-st one) and acute renal failure (the 2-nd one). In both series, the animals were divided into 3 groups: rats of the 1-st group were kept on standard feed, the rats of the other groups were got additionally to the feed turmeric (the 2-nd group) or galega (the 3-d group) (2% of feed weight). On the 3-d day of the experiment, the study of diuretic and ionuretic renal functions on an empty stomach and after water loading was performed. The concentration of ions in urine and plasma was determined by flame photometry; osmotic concentration of biological fluids - by cryoscopy; blood biochemical parameters– by colorimetric method.

Results: In diabetic against both at the background and following water loading polyuria compared to the control animals was observed. Intake of Curcuma longa resulted in a slight decrease of polyuria, but an increase in the Na+ and K+ concentration in the urine. It has been shown that turmeric and galega have a hypoglycemic effect and contribute to the normalization of plasma homeostatic parameters by improving the functional state of the kidneys. This effect was most pronounced following turmeric intake. In rats with acute renal failure both phytopreparations did not cause the changes in renal functions.

Conclusion: Phytopreparations of turmeric and galega in diabetes have a hypoglycemic effect, contribute to the normalization of plasma homeostatic parameters and improve the functional state of the kidneys. In acute renal failure, these herbal remedies have almost no effect on osmotic and ion-regulating responses

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