Effect of Potassium Sodium Hydrogen Citrate Granule on The Wall

Abstract

Wan Li, Wang Shubin, Zhao Min, Wang Yong, Cao Jingchao, Sun Xiaoyu and Ni Yongjing

Objective: To observe the effect of potassium sodium hydrogen citrate Granule on the wall stone shell of preset ureteral stent before ureteroscopy.
Methods: 263 cases of renal calculi treated in our hospital from January 2019 to June 2021 who needed ureteroscopy and successfully preset ureteral stent were investigated retrospectively. 129 cases of patients who took oral potassium sodium citrate granules 10g a day from preset ureteral stent and maintained pH between 7.6 ~ 8.0 until before ureteroscopy were classified into the experimental group, 134 patients without oral administration of any drugs were classified as the control group. The patients in the experimental group took Potassium Sodium Citrate Granules orally. The daily dose was 4 standard spoons, 1 spoonful in the morning, 1 spoonful at noon and 2 spoonfuls in the evening. Both groups of patients returned to the hospital for ureteroscopic lithotripsy after 3 weeks according to the doctor’s advice. After pulling out the ureteral stent tube during the operation, the two doctors observed whether there was wall attached stone shell on the surface of the ureteral stent tube and the thickness of the stone shell, and recorded it in a special notebook after unified opinions. Finally, weigh the weight of ureteral stent and completely scrape off the stone shell to obtain the weight of stone shell.
Results: In the experimental group, 129 ureteral stents were pulled out, of which 7 showed thin stone shells and 4 showed thicker stone shells (the thickest part ≥ 1mm). The stone shell formation rate was 8.53%, and the average stone shell weight was 0.8521 ± 0.1952 G. In the control group, 134 ureteral stents were pulled out, including 21 thin stone shells and 9 thick stone shells. The stone shell formation rate was 22.39%, and the average stone shell weight was 1.7823 ± 0.1802 G. The ureteral stent was pulled out at one time in both groups. After oral administration of youlaite, there were significant differences in stone shell formation rate, stone shell thickness and stone shell weight between the two groups (P < 0.05).
Conclusion: Potassium sodium hydrogen citrate granules can be used as an economic, effective and safe drug to reduce the formation of stone shell attached to ureteral stent and slow down the progress of stone shell thickness, which is worthy of clinical promotion.

PDF