International Journal of Diabetes & Metabolic Disorders(IJDMD)
ISSN: 2475-5451 | DOI: 10.33140/IJDMD
Impact Factor: 1.23
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Dysregulation of Hypothalamic Pituitary Adrenal (HPA) Axis in Alzheimers Disease and use of Non Selective and Selective Glucocorticoid Receptor Modulators to Improve Cognitive function: Review of Literature
Abstract
Sonia Afshariyamchlou, Arash Ardabilygazir and Issac Sachmechi
Alzheimer's disease (AD) is a relentless neurodegenerative disease affecting more than 36 million people worldwide. Increased evidence suggests stress and its synonymous elevated circulating glucocorticoid levels, due to dysregulation of Hypothalamic-Pituitary-Adrenal (HPA) axis, is an important environmental risk factor for the onset and progression of AD [1]. Here we review recent data on the effect of glucocorticoids on spontaneous activity of HPA axis with particular emphasis on AD, and how modulation of glucocorticoid (GC) levels or GC receptors (GCRs) could potentially mediate disease processes.