Digestive Neuroendocrine Tumors about 40 Cases

Abstract

R Boujarnija, F Saddouki, S Berrad, N Acharfi, L Nouakh, I Ouafki, K Oualla, Z Benbrahim S, S Arifi, A Douida, H ELfatemi, I Staouni, Alaoui Lamrani Y , Ibrahimi A and Mellas N

Neuroendocrine tumors of the digestive system account for 1% of all digestive tumors. These are a group of clinically and biologically heterogeneous neoplasms. The objective of this article is to report the epidemiological, clinical, paraclinical, histological, therapeutic, and progressive characteristics of digestive NETs in our context. Through a study of files over the period from January 2010 to September 2018, 40 cases of NET been collected in the medical oncology department of CHU HASSAN II in Fez. Clinical, paraclinical, therapeutic and evolutionary data were collected. The average age found was 50.42 years. A slight female predominance was noted with a sex ratio of 0.66. The clinical presentation was dominated by non-specific digestive symptoms. Carcinoid syndrome was found in 12.5% of patients. According to the WHO classification: 65% of patients presented well-differentiated NETs versus 30% of poorly differentiated CNE, 5% are undifferentiated NETs. The highest frequency of these tumors was observed in the D-P block (22.5%) and the small intestine (22.5%), followed by NET of unknown origin 15%.The majority of patients presented at an advanced stage (stage 4 in 65%), and the extension assessment already revealed distant metastases, particularly in the liver, and 57.5% of patients received chemotherapy.

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