De Novo Minimal Changes Disease Associated to Inoculation with Adenovirus Vector Vaccine (Sputnik V)

Abstract

Rios Maria Celeste, Weiss Natalia, Parodi Francesco, Alberton Valeria

Due to the pandemic caused by the virus SARS-CoV-2, multiple therapeutic and preventive strategies have been developed in order to avoid its propagation. Vaccines have been proved to be the most efficient means to control the spread of COVID 19, which has prevented both massive admissions of critical patients to intensive care units and the collapse of the health system from happening.

To the present day there are different tested vaccine platforms with adenovirus vectors, inactivated vaccines and nucleic acid vaccines, among others [1]. As the vaccination process moved forward around the globe, there has been a number of publications reporting on adverse renal events, which included case reports on Secondary Nephrotic Syndome derived from Minimal Changes Disease (MCD) after the application of both, nucleic acid (RNAm) and adenovirus vector vaccines.

Case presentation: male patient presented with nephrotic syndrome without microhematuria and with renal dysfunction after the application of the second dose of SPUTNIK V vaccine, which is why a renal biopsy was carried out. Such biopsy reported it was a case of MCD, which had a complete remission after six weeks of oral corticosteroids.

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