Data Analyses with ImageJ Software in Diabetic Retinopathy, By Processing the Optical Coherence Tomography Images

Abstract

D Moraru, S Istrate, C Eniceicu and P Sterian

The study is based on Optical Coherence Tomography images resulting from investigation of 24 patients (with a total of 33 eyes) with non-proliferative diabetic retinopathy and of 19 patients (with a total of 26 eyes) without diabetes mellitus as control group. Patients’ age was between 43 and 92 years old, with a mean age of 66.4 years for first group, and a mean age of 67.6 years for the second one. From this large group, after the first data evaluation, we selected patients aged 40 to 65. We evaluated daily each patient, at 9 am, 12 pm, 3 pm and 6 pm, through glycemic level and Optical Coherence Tomography investigation using Macular Cube 512x128 images acquisition type. In the same time, we made specifically measurements of photoreceptor and retinal pigment epithelium layers thickness using ImageJ software. We analysed comparatively data given by Optical Coherence Tomography tool and those obtained through direct thickness measurements for three macular zones: one central (foveola) and two circulars (para-foveolar and peri-foveolar), having 1 mm, 3 mm, respectively 6 mm in diameter. We concluded that age and time of the day are significantly factors that influence the diabetic retinopathy. We also suggest this method as further investigation tool mostly for patients at the beginning of illness discovering, in order to diminishing and even stopping its evolution.

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