Current Trends in Therapeutics Research for Alzheimers Disease

Abstract

Kaushik Bharati

Recent trends in research for Alzheimer’s disease therapeutics are very promising. Currently, a multi-pronged approach is be- ing adopted and many novel strategies are being explored. The eventual goal is to reduce the symptoms by improving neuro- transmission in the brain, which slows down disease progres- sion. Scientists are trying to block β-amyloid plaque formation using monoclonal antibodies (mAbs) by harnessing the power of the immune system. This helps to prevent clumping of the neuro- fibrils constituting the plaques, as well as clearing the β-amyloid plaques from the brain. In the last couple of years, several mAbs, including aducanumab and lecanemab have been approved by the USFDA for treating Alzheimer’s disease.

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